Chris Boutell

In situ molecular architecture of PML bodies reveals open-state columnar trinucleosome assemblies within a porous, chromatin-permissive interior

This study uses cryo-CLEM to reveal the molecular structure of PML bodies, identifying columnar trinucleosome assemblies and a porous interior that may facilitate chromatin partitioning.

Histone H2A Ubiquitination Mediates the Establishment of Reactivation-Competent HSV-1 Latent Infection

This study shows that H2AK119ub1, deposited by PRC1, is critical for HSV-1 reactivation from latency, while H3K27me3 is not.

Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription

This study identifies Daxx-mediated histone H3.3 deposition on HSV-1 DNA as a host restriction factor that limits genome decompaction and immediate-early transcription.

Interferon Dependent Immune Memory during HSV-1 Neuronal Latency Results in Increased H3K9me3 and Restriction of Reactivation by ATRX

This study shows that interferon-induced H3K9me3 and ATRX restrict HSV-1 reactivation by maintaining epigenetic memory during neuronal latency.