Organ-confined mRNA delivery and protein expression during ex vivo perfusion of porcine donor kidneys
Cristina Ballester Bergada, Ping Song, Katerina B Knudsen, Christopher L. Jaynes, Henri G. D. Leuvenink, Victor Ramon Llorente, L. Annick van Furth, Henrik Hager, Rikke Nørregaard, Jan‐Luuk Hillebrands, Anna Krarup Keller, Bente Jespersen, Jørgen Kjems, Marco Eijken
The paper demonstrates lipid nanoparticle-mediated mRNA delivery enables rapid, organ-wide protein expression in human-sized porcine donor kidneys during normothermic machine perfusion.
bioRxiv · Aug 28, 2025 · PreprintBioengineering