Marco Eijken

Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice

This study shows that blocking ActRIIA/IIB increases muscle mass and strength in mice but causes glucose intolerance and reduced voluntary activity.

Organ-confined mRNA delivery and protein expression during ex vivo perfusion of porcine donor kidneys

The paper demonstrates lipid nanoparticle-mediated mRNA delivery enables rapid, organ-wide protein expression in human-sized porcine donor kidneys during normothermic machine perfusion.

End of preservation normothermic machine perfusion of porcine kidneys after ischaemic injury reprograms metabolism and induces fibrosis after transplant despite unchanged function: insights from the renal proteome.