Matrix Stiffening Induces Mechanical Memory and Nuclear Fragility in Cardiomyocytes via Microtubule-Lamin Coupling
Nesrine Bouhrira, Sebastian Pizarro, Victor Senf, Kenneth B. Margulies
This study shows that short-term mechanical stress in cardiomyocytes leads to persistent nuclear changes and DNA damage, which can be prevented by disrupting microtubule detyrosination or the LINC complex.
bioRxiv · Jul 17, 2025 · PreprintCell Biology