Nesrine Bouhrira

This study identifies that SGLT2 inhibitors activate pantothenate kinase 1 (PANK1) in the human heart, enhancing coenzyme-A synthesis and fuel use, which may explain their clinical benefits in heart failure.

This study shows that short-term mechanical stress in cardiomyocytes leads to persistent nuclear changes and DNA damage, which can be prevented by disrupting microtubule detyrosination or the LINC complex.

The paper investigates the role of lamin A/C in cardiac fibroblasts and shows that mutations affect fibroblast function, influencing disease progression in LMNA cardiomyopathy.