Catalytic and Structural Insights into Neil3-Dependent Unhooking of Endogenous Abasic DNA Crosslink
Andrea Hušková, Barbora Landová, Viktoria Benova, Martin Klíma, Kamil Hercík, Evžen Bouřa, Jan Šilhán
This study clarifies the mechanism of NEIL3 in unhooking Ap-ICLs by showing that a processed form of NEIL3 efficiently removes crosslinks without generating strand breaks.
bioRxiv · Jan 20, 2026 · PreprintBiochemistry