Gentamicin induction of the gonococcal hicAB toxin-antitoxin encoding system and 2 impact on gene expression influencing biofilm formation and in vivo fitness in a strain specific manner
Concerta L. Holley, Vijaya Dhulipala, Adriana Le Van, Jacqueline T. Balthazar, Vincent J. Oliver, Ann E. Jerse, William Maurice Shafer
This paper shows that sub-lethal gentamicin levels increase the hicAB toxin-antitoxin system in Neisseria gonorrhoeae, reducing biofilm formation and in vivo fitness in some strains.
mBio · Jul 30, 2025Peer-reviewedMicrobiology