Author

Adriana Le Van

Henry M. Jackson FoundationORCID 0000-0002-8209-9520Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ann E. JerseiD· 3 shared Robert A. NicholasiD· 2 shared Tatum D. MortimeriD· 2 shared Yonatan H. GradiD· 2 shared Aditi MukherjeeiD· 1 shared Bryan B. GuzmániD· 1 shared Concerta L. HolleyiD· 1 shared Daniel DomingueziD· 1 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersMicrobiology

Ann E. JerseORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologymBioPeer-reviewedJul 30, 2025

Gentamicin induction of the gonococcal hicAB toxin-antitoxin encoding system and 2 impact on gene expression influencing biofilm formation and in vivo fitness in a strain specific manner

Concerta L. Holley, Vijaya Dhulipala, Adriana Le Van…·William Maurice Shafer

This paper shows that sub-lethal gentamicin levels increase the hicAB toxin-antitoxin system in Neisseria gonorrhoeae, reducing biofilm formation and in vivo fitness in some strains.

1 citation

humanmouse

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MicrobiologybioRxivPreprintJun 27, 2025

The role of the L421P mutation in Penicillin-Binding Protein 1 (PBP1) in the evolution of chromosomally mediated penicillin resistance in Neisseria gonorrhoeae

Gabriella L. Gentile, Bryan B. Guzmán, Adriana Le Van…·Robert A. Nicholas

This study shows that the ponAL421P mutation in PBP1 increases penicillin MIC above the clinical breakpoint and persists in N. gonorrhoeae despite penicillin's removal from treatment guidelines.

DOI 10.1101/2025.06.27.662027

humanwhole-genome sequencing

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MicrobiologybioRxivPreprintFeb 3, 2025

Quantifying the impact of antibiotic use and genetic determinants of resistance on bacterial lineage dynamics

David Helekal, Tatum D. Mortimer, Aditi Mukherjee…·Yonatan H. Grad

This study quantifies how antibiotic use and genetic resistance determinants affect bacterial lineage dynamics using a Bayesian model and Neisseria gonorrhoeae isolates.

5 citations

humanwhole-genome sequencing

𝕏 PostBluesky