Pharmacological Inhibition of Epac1 Protects against Pulmonary Fibrosis by Blocking FoxO3a Neddylation
Katherine Jankowski, Sarah-Eve S Lemay, Daniel Lozano‐Ojalvo, Leticia Pérez‐Rodríguez, Mélanie Sauvaget, Sandra Breuils‐Bonnet, Karina Formoso, Vineeta Jagana, Maria T. Ochoa, Shihong Zhang, Javier Milara, Julio Cortijo, Irene C. Turnbull, Steeve Provencher, Sébastien Bonnet, , Lahouaria Hadri
This study shows that inhibiting Epac1 with AM-001 reduces fibroblast proliferation and profibrotic markers, protecting against pulmonary fibrosis in mouse models and human lung slices.
European Respiratory Journal · Jul 10, 2025Peer-reviewedPhysiology