Frank Lezoualc’h

This study shows that PI5P causes mitochondrial fragmentation and dysfunction in cardiomyocytes under metabolic stress, linking endolysosomal signaling to mitochondrial metabolism.

This study shows that inhibiting Epac1 with AM-001 reduces fibroblast proliferation and profibrotic markers, protecting against pulmonary fibrosis in mouse models and human lung slices.