Irene C. Turnbull

Sotatercept Reverses SIN3a Deficiency-Driven PAH by Reprogramming BMPR2/TGF-β-HIF-1α Signaling Pathways

This study shows that Sotatercept reverses SIN3a deficiency-driven pulmonary arterial hypertension by reprogramming BMPR2/TGF-β-HIF-1α signaling pathways.

Micromachined Thermocouple Microprobe for Real-Time Thermometry of Hippocampal Slices during High-Frequency Stimulation

The paper measures temperature changes in mouse hippocampal slices during high-frequency stimulation, showing that synaptic activity increases local temperature.

Non-invasive Biomechanical Characterization of Embryos Using Microfluidic Cantilevers

This paper introduces a non-invasive method to measure embryo stiffness using microfluidic cantilevers, showing rapid and accurate ZP elasticity measurements in mouse embryos.

Pharmacological Inhibition of Epac1 Protects against Pulmonary Fibrosis by Blocking FoxO3a Neddylation

This study shows that inhibiting Epac1 with AM-001 reduces fibroblast proliferation and profibrotic markers, protecting against pulmonary fibrosis in mouse models and human lung slices.

Preliminary Insights into the Acute Molecular Responses in C2C12 Myotubes to Hyperthermia and Insulin Treatment.

This study examines gene expression changes in C2C12 myotubes under hyperthermia with and without insulin treatment, finding upregulated metabolic and stress-related genes and insulin's moderating effect on these changes.

Synergistic generation of cardiac resident-like macrophages and cardiomyocyte maturation in tissue engineered platforms

This study generates cardiac resident-like macrophages and cardiomyocytes from iPSCs to investigate their interactions in 2D and 3D settings, showing improved cardiomyocyte maturation and function when co-cultured.