Accumulation of PD-1+ TIGIT+ T cells in the liver after local antigen reactivity and during autoimmune hepatitis
Thomas Guinebretière, Anaïs Cardon, Jean‐Paul Judor, Pierre-Jean Gavlovsky, Fanny Roux, Virginie Huchet, Caroline Chevalier, Marion Khaldi, Edouard Bardou‐Jacquet, Laure Elkrief, Adrien Lannes, Christine Silvain, Matthieu Schnee, Florence Tanné, Sara Lemoinne, , Amédée Renand
The paper shows that peripheral immunization drives liver-antigen-specific T cell accumulation marked by PD-1 and TIGIT co-expression, which correlates with AIH disease activity.
bioRxiv · Aug 29, 2025 · PreprintImmunology