The paper shows that peripheral immunization drives liver-antigen-specific T cell accumulation marked by PD-1 and TIGIT co-expression, which correlates with AIH disease activity.

bioRxiv · Aug 29, 2025 · PreprintImmunology

Clonal analysis of SepSecS-specific CD4 T cells reveals a new HLA-DPA102:01/HLA-DPB101:01-restricted immunodominant epitope in autoimmune hepatitis

Thomas Guinebretière, Alexandra Garcia, Chuang Dong, Laura Bernier, Virginie Huchet, Pierre-Jean Gavlovsky, Laurine Gil, Sakina Ado, Caroline Chevalier, Jean‐Paul Judor, Béatrice Clemenceau, Marion Khaldi, Edouard Bardou‐Jacquet, Laure Elkrief, Adrien Lannes, , Amédée Renand

bioRxiv · Aug 29, 2025 · PreprintImmunology

The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseases

Anaïs Cardon, Thomas Guinebretière, Chuang Dong, Laurine Gil, Sakina Ado, Pierre-Jean Gavlovsky, Martin Braud, Richard Danger, Christoph Schultheiß, Aurélie Doméné, Perrine Paul‐Gilloteaux, Caroline Chevalier, Laura Bernier, Jean‐Paul Judor, Cynthia Fourgeux, , Amédée Renand

This study identifies the transcriptional profile of circulating autoreactive CD4 T cells in autoimmune liver diseases and shows their functional relationship to liver-specific pathogenic clones.

Nature Communications · Jan 29, 2025Peer-reviewedImmunology

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Accumulation of PD-1+ TIGIT+ T cells in the liver after local antigen reactivity and during autoimmune hepatitis

Clonal analysis of SepSecS-specific CD4 T cells reveals a new HLA-DPA1*02:01/HLA-DPB1*01:01-restricted immunodominant epitope in autoimmune hepatitis

The immune profile of circulating autoreactive CD4 T cells is imprinted through tissue activation during autoimmune liver diseases

Clonal analysis of SepSecS-specific CD4 T cells reveals a new HLA-DPA102:01/HLA-DPB101:01-restricted immunodominant epitope in autoimmune hepatitis