Structural Basis for pH-Gating of the K+ Channel TWIK1 at the Selectivity Filter
Toby S. Turney, Vivian Li, Stephen Graf Brohawn
This study presents cryo-EM structures of TWIK1 at different pH levels, revealing how protonation of an extracellular histidine triggers conformational changes that gate the K+ channel.
Nature Communications · Jun 9, 2022Peer-reviewedNeuroscience