JNJ-55511118 Stabilizes a Desensitized-like Conformation of γ8-Containing AMPA Receptors through Long-Range Allosteric Modulation
Paola Carrillo Flores, Vladimir Berka, Vasanthi Jayaraman
This study shows JNJ-118 stabilizes a desensitized-like conformation of γ8-containing AMPA receptors through long-range allosteric modulation without disrupting the AMPAR-γ8 complex.
bioRxiv · Dec 12, 2025 · PreprintBiochemistry