Vasanthi Jayaraman

GluDs are ionotropic dopamine receptors tuned by G-proteins

The paper identifies dopamine as a direct agonist of GluDs, showing G-protein regulation of their activity and implications for neurological diseases.

Rheb membrane orientation dynamics and functional consequences elucidated by molecular simulations, single-molecule-FRET and signaling assays

This study uses simulations and assays to show Rheb switches between membrane orientations, affecting mTORC1 activity.

Memantine Inhibits Calcium-Permeable AMPA Receptors

This study shows memantine inhibits calcium-permeable AMPA receptors, revealing a new mechanism distinct from NMDA receptors and suggesting therapeutic potential for neurological disorders.

Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs

This study shows that glutamate gating of AMPA receptors is temperature sensitive and distinct from PAM-induced gating, revealing conserved structural motifs and desensitization mechanisms.

Rewired m6A methylation of promoter antisense RNAs in Alzheimer disease regulates global gene transcription in the 3D nucleome

The paper identifies AD-associated changes in m6A methylation on promoter antisense RNAs and shows their role in regulating gene expression and neuronal survival in Alzheimer's disease.

Bi-directional allosteric pathway in NMDA receptor activation and modulation

This study identifies a bidirectional allosteric pathway between the extracellular and transmembrane domains of NMDA receptors, revealing how conformational changes in one domain influence the other.