Muscle Stem Cell Niche Dysregulation in Volumetric Muscle Loss Injury
Shannon E. Anderson, Woojin M. Han, Vunya Srinivasa, Mahir Mohiuddin, Marissa A. Ruehle, Austin Moon, Eunjung Shin, Cheryl L. San Emeterio, Molly E. Ogle, Edward A. Botchwey, Nick J. Willett, Young C. Jang
This study investigates the effects of different-sized volumetric muscle loss injuries on muscle regeneration, finding that 3 mm injuries represent a critical threshold with significant fibrosis, inflammation, and impaired regeneration.
bioRxiv · Jun 13, 2018 · PreprintBioengineering