Nick J. Willett

This paper establishes a biobanking pipeline for primary human satellite cells and fibro-adipogenic progenitors, demonstrating their phenotypic stability and utility in muscle research.

This paper introduces a second lyophilization step to improve collagen scaffold handling and small molecule loading efficiency for regenerative medicine.

A feature learning model identifies cytokine profiles and signaling pathways predictive of mesenchymal stromal cell therapeutic efficacy in a rat osteoarthritis model.

This paper develops a hydrogel system that combines mechanical reinforcement with affinity-controlled BMP-2 release to improve bone regeneration in rat models.

This paper develops a composite microfiber-hydrogel scaffold using melt-electrowriting to enhance muscle tissue engineering by improving mechanical strength, alignment, and myoblast differentiation.

This study identifies an aberrant FAP subpopulation in VML that drives fibrosis and presents potential targets for scarless muscle regeneration.

This study shows that Cyr61 delivery enhances angiogenesis during bone fracture repair, particularly in fractures with stable fixation, and may have therapeutic potential for poor vascularization.

Bilayer FTY720-nanofiber scaffolds promote complete oral wound closure in a mouse model by modulating pro-regenerative immune and stromal cells.

This study shows that delivering a stable isomer of Resolvin D1 via a hydrogel improves muscle regeneration and reduces inflammation in volumetric muscle loss injuries.

This study shows FK506 induces bone formation in human cells and two in vivo models, and can be used alone or with BMP-2 for spine disorders.

This study shows JAG1 promotes bone regeneration in mice by activating osteogenic pathways in cranial neural crest cells, independent of canonical NOTCH signaling.

This study identifies a non-canonical JAG1 signal to JAK2 pathway that mediates osteoblast commitment in cranial neural crest cells, independent of the canonical NOTCH pathway.

This study investigates the effects of different-sized volumetric muscle loss injuries on muscle regeneration, finding that 3 mm injuries represent a critical threshold with significant fibrosis, inflammation, and impaired regeneration.

This paper develops a wireless implantable sensor to measure axial strain in rodent bone defects, showing it can track mechanical cues during healing.