Edward A. Botchwey

This paper introduces Volumetric Scattering Microscopy (VSM), a computational framework for 3D fluorescence imaging in scattering biological media, achieving high-fidelity volumetric reconstruction across various samples.

PAVR enables high-resolution volumetric imaging of cells using a physics-aware framework trained on simulated data, demonstrating applications in tracking subcellular structures and analyzing cardiac cell dynamics.

The paper shows that exogenous sphingomyelinase increases MSC-derived EV yield and alters their cargo, enhancing therapeutic effects in a murine wound model.

This study maps sphingolipid dynamics in macrophages during inflammation, identifying resolving and non-resolving metabolites and suggesting targeted therapeutic strategies.

This study shows that sphingomyelinase treatment alters lipid and protein metabolites in MSCs, enhancing their immunomodulatory properties similar to cytokine-based priming.

This study identifies an aberrant FAP subpopulation in VML that drives fibrosis and presents potential targets for scarless muscle regeneration.

Bilayer FTY720-nanofiber scaffolds promote complete oral wound closure in a mouse model by modulating pro-regenerative immune and stromal cells.

This study shows that delivering a stable isomer of Resolvin D1 via a hydrogel improves muscle regeneration and reduces inflammation in volumetric muscle loss injuries.

This study shows that neuroinflammation and lipid dysregulation contribute to social stress-induced cognitive deficits in sickle cell disease using a mouse model.

This study investigates the effects of different-sized volumetric muscle loss injuries on muscle regeneration, finding that 3 mm injuries represent a critical threshold with significant fibrosis, inflammation, and impaired regeneration.