Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign
T. Aggarwal, W. A. Hansen, J. Hong, A. Ganguly, D. M. York, S. D. Khare, E. C. Izgu
This paper redesigns an archaeal DNA polymerase to catalyze non-natural phosphoramidate linkages using structure-guided mutations.
bioRxiv · Dec 28, 2021Biochemistry