Author

S. D. Khare

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Ganguly· 1 shared B. J. Yachnin· 1 shared C. A. S. A. Minetti· 1 shared C. Markosian· 1 shared D. Balamurugan· 1 shared D. M. York· 1 shared D. P. Remeta· 1 shared E. C. Izgu· 1 shared

Activity by Year

2021-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

A. Ganguly

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign

T. Aggarwal, W. A. Hansen, J. Hong, A. Ganguly, D. M. York, S. D. Khare, E. C. Izgu

This paper redesigns an archaeal DNA polymerase to catalyze non-natural phosphoramidate linkages using structure-guided mutations.

bioRxiv · Dec 28, 2021Biochemistry

Structural models of SARS-CoV-2 Omicron variant in complex with ACE2 receptor or antibodies suggest altered binding interfaces

J. H. Lubin, C. Markosian, D. Balamurugan, R. Pasqualini, W. Arap, S. K. Burley, S. D. Khare

The paper generates structural models of the SARS-CoV-2 Omicron variant bound to ACE2 and antibodies, revealing altered binding interfaces and neutralization escape mechanisms.

bioRxiv · Dec 12, 2021Biophysics

Massively parallel, computationally-guided design of a pro-enzyme

B. J. Yachnin, L. R. Azouz, R. E. White, C. A. S. A. Minetti, D. P. Remeta, V. M. Tan, J. M. Drake, S. D. Khare

This paper designs pro-enzymes using computational methods and validates their activity regulation through protease cleavage.

bioRxiv · Mar 25, 2021Biophysics