Author

T. Aggarwal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. C. Izgu· 5 shared B. Gutierrez· 2 shared H. Erguven· 2 shared J. Hong· 2 shared K. Hast· 2 shared L. Wang· 2 shared M. Baci· 2 shared M. R. L. Stone· 2 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersBiochemistry

E. C. Izgu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Small-Molecule Approach to Bypass In Vitro Selection of New Aptamers: Designer Pre-Ligands Turn Baby Spinach into Sensors for Reactive Inorganic Targets

T. Aggarwal, L. Wang, B. Gutierrez, H. Guven, H. Erguven, E. C. Izgu

This paper develops a small-molecule approach to detect reactive inorganic targets using pre-ligands and the Baby Spinach aptamer, bypassing in vitro selection and enabling cell-based sensing.

bioRxiv · Jul 29, 2023 · PreprintBiochemistry

Direct Assessment of Nitrative Stress in Lipid Environments: Applications of a Designer Lipid-Based Biosensor for Peroxynitrite

B. Gutierrez, T. Aggarwal, H. Erguven, M. R. L. Stone, C. Guo, A. Alyssa Bellomo, E. Abramova, E. Stevenson, A. Gow, E. C. Izgu

This paper develops a lipid-based biosensor to directly detect peroxynitrite in lipid environments, demonstrating its utility in live cells and lung tissue.

bioRxiv · Jun 22, 2022Biochemistry

Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects

J. Rietdijk, T. Aggarwal, P. Georgieva, M. Lapins, J. Carreras-Puigvert, O. Spjuth

The paper uses Cell Painting to assess combination effects of BPA, CTAB, and DBTDL on human cell lines, showing dose- and combination-dependent morphological changes.

bioRxiv · Feb 10, 2022Pharmacology & Toxicology

MicroRNA Detection in Biological Media Using a Split Aptamer Platform

L. Wang, K. Hast, T. Aggarwal, M. Baci, J. Hong, E. C. Izgu

This paper develops a split aptamer platform for detecting miRNAs in biological media with high selectivity and sensitivity.

bioRxiv · Jan 17, 2022 · PreprintBiochemistry

Introducing a New Bond-Forming Activity in an Archaeal DNA Polymerase by Structure-Guided Enzyme Redesign

T. Aggarwal, W. A. Hansen, J. Hong, A. Ganguly, D. M. York, S. D. Khare, E. C. Izgu

This paper redesigns an archaeal DNA polymerase to catalyze non-natural phosphoramidate linkages using structure-guided mutations.

bioRxiv · Dec 28, 2021Biochemistry

Bioorthogonal Functionalization of Material Surfaces with Bioactive Molecules

K. Hast, M. R. L. Stone, Z. Jia, M. Baci, T. Aggarwal, E. C. Izgu

This paper introduces a bioorthogonal surface functionalization method using tetrazine ligation to graft bioactive molecules, demonstrating improved cytocompatibility and antimicrobial properties.

bioRxiv · Oct 1, 2021Biochemistry