The adequacy of tissue microarrays in the assessment of inter- and intra-tumoural heterogeneity of infiltrating lymphocyte burden in leiomyosarcoma
A. T. Lee, W. Chew, M. J. Smith, D. C. Strauss, C. Fisher, A. J. Hayes, I. Judson, K. Thway, R. L. Jones, P. H. Huang
This study evaluates the adequacy of tissue microarrays for assessing TIL burden heterogeneity in leiomyosarcoma and finds that 1-3 cores suffice for ordinal categorization but more are needed for accurate absolute counts.
bioRxiv · Sep 10, 2018Cancer Biology