Author

P. H. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:differential expression· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2

Frequent Co-Authors

J. Burns· 3 shared K. Thway· 3 shared A. Arthur· 2 shared C. Wilding· 2 shared L. Krasny· 2 shared M. Chadha· 2 shared N. C. Lima· 2 shared R. Jones· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCancer Biology

J. Burns

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Proteomic Features of Adolescents and Young Adults with Soft Tissue Tumours

Y. B. Tam, K. Low, H. PS, M. Chadha, J. Burns, C. Wilding, A. Arthur, T. Chen, K. Thway, A. Sadanandam, R. Jones, P. H. Huang

This study compares proteomic profiles of adolescents and young adults with soft tissue tumours to older adults, identifying age-specific molecular features and potential therapeutic targets.

bioRxiv · Nov 18, 2023Cancer Biology

Proteomic characterisation of Sarculator nomogram-defined risk groups in soft tissue sarcomas of the extremities and trunk wall

M. Chadha, S. Iadecola, A. Jenks, J. Burns, A. Arthur, V. Pankova, C. Wilding, D. Callegaro, D. Strauss, K. Thway, A. Gronchi, R. Jones, R. Miceli, S. Pasquali, P. H. Huang

This study identifies a DNA replication protein signature (SPM6) that improves risk stratification in soft tissue sarcomas when combined with the Sarculator nomogram.

bioRxiv · Nov 14, 2023 · PreprintCancer Biology

Targeting the Src pathway enhances the efficacy of selective FGFR inhibitors in cancers with FGFR3 alterations

N. C. Lima, E. Atkinson, T. D. Bunney, M. Katan, P. H. Huang

This study shows that combining Src pathway inhibitors with FGFR inhibitors improves efficacy in cancers with FGFR3 mutations by overcoming intrinsic resistance.

bioRxiv · Apr 4, 2020Cancer Biology

A mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

L. Krasny, P. Bland, J. Burns, N. C. Lima, P. T. Harrison, L. Pacini, M. L. Elms, J. Ning, V. G. Martinez, Y.-R. Yu, S. E. Acton, P.-C. Ho, F. Calvo, A. Swain, B. A. Howard, , P. H. Huang

The paper develops a mouse SWATH-MS spectral library and a deconvolution method to analyze proteomic changes in human tumor xenografts, revealing host-tumor interactions.

bioRxiv · Feb 3, 2020Biochemistry

Conduit integrity is compromised during acute lymph node expansion

V. G. Martinez, V. Pankova, L. Krasny, T. Singh, I. J. White, A. C. Benjamin, S. Dertschnig, H. L. Horsnell, J. Kriston-Vizi, J. J. Burden, P. H. Huang, C. J. Tape, S. E. Acton

This study investigates how conduit integrity in lymph nodes changes during acute expansion, finding that while the structure is disrupted, FRC-FRC contacts remain intact and antigen flow becomes leaky.

bioRxiv · Mar 21, 2019Immunology

The adequacy of tissue microarrays in the assessment of inter- and intra-tumoural heterogeneity of infiltrating lymphocyte burden in leiomyosarcoma

A. T. Lee, W. Chew, M. J. Smith, D. C. Strauss, C. Fisher, A. J. Hayes, I. Judson, K. Thway, R. L. Jones, P. H. Huang

This study evaluates the adequacy of tissue microarrays for assessing TIL burden heterogeneity in leiomyosarcoma and finds that 1-3 cores suffice for ordinal categorization but more are needed for accurate absolute counts.

bioRxiv · Sep 10, 2018Cancer Biology

Primary cilia mediate diverse kinase inhibitor resistance mechanisms in cancer

A. D. Jenks, S. Vyse, J. P. Wong, D. Keller, T. Burgoyne, A. Shoemark, M. de la Roche, A. Tsalikis, M. Michaelis, J. Cinatl, P. H. Huang, B. E. Tanos

The paper investigates how primary cilia contribute to kinase inhibitor resistance in cancer by altering cilia structure and function, leading to enhanced hedgehog pathway activation and drug resistance.

bioRxiv · Aug 25, 2017Cell Biology