A. J. Hayes

Genetic heterogeneity in the Salmonella Typhi Vi capsule locus: A population genomic study from Fiji

This study examines genetic diversity in the Vi capsule locus of Salmonella Typhi in Fiji, identifying convergent evolution of tviE mutations globally and highlighting the need for further functional analysis.

IL-27 maintains cytotoxic Ly6C+ gamma delta T cells that arise from immature precursors

The paper identifies immature and mature subsets of IFNγ-producing γδ T cells, showing IL-27 supports cytotoxic function in mature cells but not immature ones.

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

The paper shows extensive genomic overlap between Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis, including shared genes and recombination events, with implications for vaccine development.

Burkholderia PglL enzymes are serine preferring oligosaccharidetransferases which target conserved proteins across the Burkholderia genus

Chemokine receptors ACKR2 and CCR1 coordinate macrophage dynamics and mammary gland development

The paper shows ACKR2 and CCR1 regulate macrophage dynamics and mammary gland development by controlling CCL7 levels and macrophage movement.

Sorting for CCR7-positivity enriches for a dendritic cell population with enhanced antigen-presenting capacity and anti-tumour potency

This study shows that selecting dendritic cells with high CCR7 expression improves their ability to migrate to lymph nodes and enhance anti-tumour immune responses in melanoma models.

The adequacy of tissue microarrays in the assessment of inter- and intra-tumoural heterogeneity of infiltrating lymphocyte burden in leiomyosarcoma

This study evaluates the adequacy of tissue microarrays for assessing TIL burden heterogeneity in leiomyosarcoma and finds that 1-3 cores suffice for ordinal categorization but more are needed for accurate absolute counts.