Activation of GPR116/ADGRF5 by its tethered agonist requires key amino acids in extracellular loop 2 of the transmembrane domain
J. P. Bridges, C. Safina, B. Picard, K. Brown, A. Filuta, R. Bouhelal, S. Patel, K. Seuwen, W. E. Miller, M.-G. Ludwig
This study identifies key amino acids in extracellular loops 2/3 and transmembrane7 of GPR116 that are critical for tethered agonist-mediated activation.
bioRxiv · Apr 1, 2021 · PreprintCell Biology