TP53 knockout in MCF7 breast cancer cells induces sensitivity to fluoropyrimidine drugs.
J. M. Warrington, S. Mehta, V. F. Moy, J. Patel, C. Liu, A. Rago, C. McTighe, I. Delgado, C. Banister, W. Gmeiner, P. J. Buckhaults
This study shows TP53 knockout in breast cancer cells increases sensitivity to fluoropyrimidine drugs like F10, with DNA incorporation as a key mechanism.
bioRxiv · Feb 10, 2022 · PreprintCancer Biology