Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4
T. P. Dao, A. Rajendran, S. K. K. Galagedera, W. Haws, C. A. Castaneda
This study shows that the N-terminal disordered regions and proline-rich domain regulate phase separation in UBQLN1, UBQLN2, and UBQLN4, with distinct temperature dependencies.
bioRxiv · Sep 27, 2023Biophysics