Author

S. K. K. Galagedera

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Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

C. A. Castaneda· 2 shared T. P. Dao· 2 shared A. Chaudhuri· 1 shared A. Rajendran· 1 shared J. D. Schmit· 1 shared S. E. Enos· 1 shared W. Haws· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

C. A. Castaneda

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2 papers

Recent·Most cited

BiophysicsbioRxivSep 27, 2023

Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4

T. P. Dao, A. Rajendran, S. K. K. Galagedera…·C. A. Castaneda

This study shows that the N-terminal disordered regions and proline-rich domain regulate phase separation in UBQLN1, UBQLN2, and UBQLN4, with distinct temperature dependencies.

DOI 10.1016/j.bpj.2023.11.3401

experimental assay

𝕏 PostBluesky

BiophysicsbioRxivMar 13, 2023

Decoding optimal ligand design for multicomponent condensates

S. K. K. Galagedera, T. P. Dao, S. E. Enos…·C. A. Castaneda

This study identifies optimal polyubiquitin ligand architectures that promote UBQLN2 phase separation by analyzing the energetic penalties and spatial configurations of Ub units.

DOI 10.1073/pnas.2306638120

statistical modelchromatin & epigenetic regulation

𝕏 PostBluesky