Author

W. J. Xie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

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Research Focus:chromatin & epigenetic regulation· 3 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:Hi-C· 1 Assay:imaging· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

L. Meng· 2 shared L. Zhang· 2 shared S. Liu· 2 shared Y. Q. Gao· 2 shared B. Zhang· 1 shared C. Gu· 1 shared X. Cai· 1 shared Y. Qi· 1 shared

Activity by Year

2017-2019 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

L. Meng

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3 papers

Recent·Most cited

Characterizing chromatin folding coordinate and landscape with deep learning

W. J. Xie, Y. Qi, B. Zhang

The paper uses a variational autoencoder to analyze chromatin structure fluctuations and identifies a reaction coordinate for chromatin folding, revealing insights into TAD formation and folding energetics.

bioRxiv · Oct 30, 2019Biophysics

DNA Methylation Landscape Reflects the Spatial Organization of Chromatin in Different Cells

L. Zhang, W. J. Xie, S. Liu, L. Meng, C. Gu, Y. Q. Gao

The paper shows DNA methylation's long-range and local correlations reflect chromatin spatial organization across different cell types.

bioRxiv · May 3, 2017Biophysics

Structural Modeling of Chromatin Integrates Genome Features and Reveals Chromosome Folding Principle

W. J. Xie, L. Meng, S. Liu, L. Zhang, X. Cai, Y. Q. Gao

The paper constructs 3D chromatin structures from Hi-C data and shows how chromatin compartments A and B are defined by distinct domain types with different loop sizes and contact patterns.

bioRxiv · Apr 12, 2017Biophysics