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5 papers
Recent·Most cited
Z. Cai, Y. He, S. Liu, Y. Xue, H. Quan, L. Zhang, Y. Q. Gao
The paper quantifies species-specific CpG distribution patterns across genomic scales and shows their correlation with chromatin structure in mammals and avians.
bioRxiv · Feb 20, 2020 · PreprintEvolutionary Biology
Y. Xue, Y. Yang, H. Tian, H. Quan, S. Liu, L. Zhang, Y. Q. Gao
The paper examines how 3D chromatin structure and DNA methylation change in cancer, showing increased segregation of chromatin domains and methylation differences that correlate with transcriptional changes.
bioRxiv · Jan 13, 2020 · PreprintCancer Biology
S. Liu, L. Zhang, H. Quan, H. Tian, L. Meng, L. Yang, H. Feng, Y. Q. Gao
The paper identifies forest and prairie genomic domains based on CpG island density and shows their role in shaping cell-type-specific chromatin structures and genomic properties through phase separation mechanisms.
bioRxiv · Jan 28, 2018Biophysics
L. Zhang, W. J. Xie, S. Liu, L. Meng, C. Gu, Y. Q. Gao
The paper shows DNA methylation's long-range and local correlations reflect chromatin spatial organization across different cell types.
bioRxiv · May 3, 2017Biophysics
W. J. Xie, L. Meng, S. Liu, L. Zhang, X. Cai, Y. Q. Gao
The paper constructs 3D chromatin structures from Hi-C data and shows how chromatin compartments A and B are defined by distinct domain types with different loop sizes and contact patterns.
bioRxiv · Apr 12, 2017Biophysics