X. Cai

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

Correlative multiscale 3D imaging of mouse primary and metastatic tumors by sequential light sheet and confocal fluorescence microscopy

This paper develops a method to obtain correlative multiscale 3D images of mouse tumors using sequential light sheet and confocal fluorescence microscopy, enabling spatial analysis of immune responses and metastasis.

CCR7+ Dendritic Cells Define a Type 17 Module in Psoriasis

The paper identifies CCR7+ dendritic cells as the primary source of IL-23 in psoriasis, linking them to type 17 inflammation and relapse.

Force-Enhanced Sensitive Detection of New DNA-Interactive Agents from Microorganisms at the Single-Molecule Level

This paper introduces a single-molecule stretching assay to detect DNA-intercalating agents from microorganisms, identifying two strains and three compounds with anti-cancer activity.

An effector XopL enhances ethylene biosynthesis to promote Xanthomonas fragariae infection in strawberry

This study identifies XopL as an effector that enhances ethylene biosynthesis in strawberry, promoting Xanthomonas fragariae infection by stabilizing FveACO9 and increasing ACO activity.

Identification of a Conserved B-Cell Epitope on the Capsid Protein of Porcine Circovirus Type 4

This study identifies a conserved B-cell epitope on the PCV4 capsid protein, which could aid in vaccine and detection strategies for PCV4.

Evaluating computational efforts and physiological resolution of mathematical models of cardiac tissue

The paper evaluates five mathematical models of cardiac tissue to assess their computational efficiency and physiological accuracy for different tissue sizes and resolutions.

Multi-gradient Permutation Survival Analysis Identifies Mitosis and Immune Signatures Steadily Associated with Cancer Patient Prognosis

The paper introduces MEMORY, a method to identify GEARs associated with cancer prognosis, finding mitosis-related genes in LUAD and immunity-related genes in BRCA.

The Xanthomonas fragariae effector XopK suppresses stomatal immunity by perturbing abscisic acid signaling in strawberry

This study identifies XopK, an effector from Xanthomonas fragariae, which suppresses stomatal immunity by disrupting abscisic acid signaling in strawberries, leading to increased susceptibility to infection.

PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure

This study shows PRMT5 deficiency disrupts Nur77 methylation, impairing endometrial stromal cell differentiation and contributing to recurrent implantation failure.

metaExpertPro: a computational workflow for metaproteomics spectral library construction and data-independent acquisition mass spectrometry data analysis

metaExpertPro constructs metaproteomics spectral libraries and analyzes DIA-MS data, achieving high peptide quantification and low FDR in human fecal samples.

Mycobacterial DnaQ is an Alternative Proofreader Ensuring DNA Replication Fidelity

This study shows that mycobacterial DnaQ acts as an alternative proofreader, working with the PHP domain to maintain DNA replication fidelity and prevent mutations.

Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation

This study identifies RAP2 GTPase as a central integrator of cytoskeletal signals in Hippo pathway regulation, showing its role in mediating responses to cytoskeletal changes and its impact on Hippo kinase activity.

Lactate activates the mitochondrial electron transport chain independent of its metabolism

This study shows lactate activates the mitochondrial electron transport chain without being metabolized, suppressing glycolysis and enhancing oxidative phosphorylation in various cell types.

Inflammation plays a critical role in damage to the bronchiolar epithelium induced by Trueperella pyogenes in vitro and in vivo

This study investigates T. pyogenes-induced damage to bronchiolar epithelium in vitro and in vivo, identifying inflammatory pathways and potential therapeutic targets.

A Gpr35 tuned gut-brain metabolic axis regulates depressive-like behavior

This study identifies Gpr35 as a regulator of a gut-brain metabolic axis that influences depressive-like behavior in mice, highlighting microbial metabolites as potential therapeutic targets.

Hippo Signaling Modulates Mechano-inflammatory Responses of Chondrocytes

This study shows that Hippo signaling modulates chondrocyte responses to mechanical overload by regulating NF-kappaB-mediated inflammation and matrix degradation.

A comparison of behavior paradigms assessing spatial memory in tree shrew

This study compares behavior paradigms for assessing spatial memory in tree shrews, finding the cheeseboard task most sensitive to spatial memory deficits after hippocampal lesions.

Toleration of Frameshift Mutations in mRNA Sequences Encoding the N-terminal Peptides of Bacterial Type III Effectors

The paper uses computational methods to analyze mRNA sequences of bacterial type III and IV effectors, finding that type III effectors show high frameshift tolerance in secretion signals, while type IV show low tolerance.

A tissue injury repair pathway distinct but parallel to host pathogen defense

This study identifies IL24 as a tissue repair pathway parallel to IFN-mediated host defense, showing its role in epithelial and mesenchymal regeneration after injury.

MATR3-antisense LINE1 RNA meshwork scaffolds higher-order chromatin organization

The paper shows MATR3 and antisense LINE1 RNAs form a meshwork that organizes chromatin, and their disruption causes chromatin reorganization.

Electron tomography analysis of the prolamellar body and its transformation into grana thylakoids in the cryofixed Arabidopsis cotyledon

This study uses electron tomography to analyze the structural transformation of prolamellar bodies into grana thylakoids in Arabidopsis cotyledons and identifies the role of CURT1 proteins in this process.

HBV enveloped particle secretion is positively regulated by GRP78 through direct interaction with preS1

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

Improved reference genome annotation of Brassica rapa by PacBio RNA sequencing

The paper improves the reference genome annotation of Brassica rapa using PacBio RNA sequencing, identifying novel genes, correcting splicing errors, and characterizing alternative splicing and lncRNAs.

Mosaic Evolution of Beta Barrel Porin Encoding Genes in Escherichia coli

The paper identifies mosaic evolution in multiple beta-barrel porin genes in E. coli, showing local recombination and sequence variation that may help bacteria evade environmental threats.

Reference genome and resequencing of 305 accessions provide insights into spinach evolution, domestication and genetic basis of agronomic traits

This study presents a chromosome-scale spinach reference genome and resequences 305 accessions to explore evolution, domestication, and genetic basis of agronomic traits.

Survival mechanism of a novel marine multistress-tolerant Meyerozyma guilliermondii GXDK6 under high NaCl stress as revealed by integrative omics analysis

This study identifies the survival mechanism of Meyerozyma guilliermondii GXDK6 under high NaCl stress using integrative omics analysis, revealing key genes and pathways involved in salt tolerance.

Inhibition of aryl hydrocarbon receptor signaling promotes the terminal differentiation of human erythrocytes

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

Profiling tumor immune microenvironment of non-small cell lung cancer using multiplex immunofluorescence

This study profiles the tumor immune microenvironment of NSCLC using multiplex immunofluorescence, identifying three immune subtypes and an immune-related risk score for prognosis prediction.

Structural basis for ligand recognition and G protein-coupling promiscuity of the cholecystokinin A receptor

The paper presents cryo-EM structures of CCKAR with different G proteins to elucidate its G protein coupling promiscuity and ligand recognition mechanism.