Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering
W. Orapiriyakul, M. Tsimbouri, P. Childs, P. Campsie, J. Wells, M. M. Fernandez, K. Burgess, E. Tanner, M. Tassieri, D. Meek, M. Vassalli, M. Biggs, M. Salmeron-Sanchez, R. Oreffo, S. Reid, M. Dalby
This study shows that nanovibrational stimulation of MSCs induces ROS and low-level inflammation, mimicking natural bone healing, and uses this to design a 3D bone tissue scaffold.
bioRxiv · Apr 10, 2020Bioengineering