M. Salmeron-Sanchez

Matrix viscoelasticity controls epithelial cell mechanobiology through dimensionality

This study investigates how matrix viscoelasticity and spatial confinement influence epithelial cell mechanobiology and migration on soft and stiff substrates, revealing distinct effects on cell behavior.

Bioactive coatings on 3D printed polycaprolactone scaffolds for bone regeneration: a novel murine femur defect model for examination of the biomaterial capacity for repair.

This study evaluates bioactive coatings on 3D printed PCL-TMA900 scaffolds for bone regeneration using a murine femur defect model, finding that Laponite/BMP-2 coating significantly promotes bone formation without heterotopic bone formation.

Bioactive coatings on 3D printed scaffolds for bone regeneration: Translation from in vitro to in vivo models and the impact of material properties and growth factor concentration.

This study evaluates bioactive coatings on 3D-printed PCL-TMA scaffolds for bone regeneration, showing in vitro osteogenic response but no significant in vivo bone formation.

Engineered 3D environments reprogram fibroblast-mediated inflammation in rheumatoid Arthritis.

This study shows that 3D environments influence fibroblast inflammation in rheumatoid arthritis, with soft hydrogels promoting a resolving phenotype and stiff scaffolds restoring inflammatory profiles.

Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells

This study develops a bioengineered niche that maintains long-term haematopoietic stem cells by recreating physiological extracellular matrix organisation, supporting their survival and function without media supplementation.

Collagen-VI expression is negatively mechanosensitive in pancreatic cancer cells and supports the metastatic niche

The paper shows Collagen-VI is upregulated in pancreatic cancer cells on soft substrates and promotes metastasis by supporting the metastatic niche.

PEA polymer-coated nanotopography delivers solid-state BMP2, enhances mesenchymal stem cell adhesion, prevents bacterial biofilm formation and protects cells from quorum sensing virulence factors

Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineering

This study shows that nanovibrational stimulation of MSCs induces ROS and low-level inflammation, mimicking natural bone healing, and uses this to design a 3D bone tissue scaffold.

Lithium directs embryonic stem cell differentiation versus hemogenic endothelium

This paper identifies lithium as a Wnt agonist that stabilizes β-catenin and drives ESC differentiation into hemogenic endothelium and HSCs in vitro.

Designing Topographically Textured Microparticles For Induction and Modulation of Osteogenesis in Mesenchymal Stem Cell Engineering

This study shows that topographically textured microparticles can enhance osteogenic markers in mesenchymal stem cells without exogenous factors.

Boron induces osteogenesis by stimulating NaBC1 in cooperation with BMPR1A

This study shows boron enhances osteogenesis in MSCs by activating the BMP canonical pathway through NaBC1 interaction with BMPR1A and integrins, without using growth factors.

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

This study uses nanovibration to induce osteogenic differentiation in MSCs without exogenous growth factors, identifying cholesterol sulphate and fludrocortisone acetate as potent bioactive metabolites.

Material-Driven Fibronectin Assembly Rescues Matrix Defects due to Mutations in Collagen IV in Fibroblasts

This study shows that fibronectin-coated biomaterials can rescue matrix and cellular defects in fibroblasts with collagen IV mutations.

Engineered full-length Fibronectin-based hydrogels sequester and present growth factors to promote regenerative responses in vitro and in vivo

This study develops fibronectin-based hydrogels that present growth factors to enhance angiogenesis and bone regeneration in vitro and in vivo.

Nanotopography reveals metabolites that maintain the immunosuppressive phenotype of mesenchymal stem cells

This study shows nanotopography can control MSC immunomodulatory capacity by modulating intracellular tension and oxidative glycolysis, and identifies bioactive metabolites that influence MSC function.