Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex
T. Xia, D. Chen, X. Liu, H. Qi, W. Wang, H. Chen, T. Ling, W. Otkur, C.-S. Zhang, J. Kim, S.-C. Lin, H.-l. Piao
This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.
bioRxiv · Sep 27, 2021Cancer Biology