Author

W. Sebastian Kamau

MIT Media Lab

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Synthetic Biology· 1

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Approach:experimental assay· 1 Organism:mouse· 1

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Ceili L. PengiD· 1 shared Julien Freeman· 1 shared Kevin M. EsveltiD· 1 shared Zachary J Hill· 1 shared

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2026-2026 · peak 1/yr

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Ceili L. PengORCID

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Synthetic BiologyThe CRISPR JournalPeer-reviewedJun 1, 2026

Increasing the effective gene drive homing rate by targeting the haploinsufficient spermatogenesis gene KLHL10

Ceili L. Peng, W. Sebastian Kamau, Julien Freeman…·Kevin M. Esvelt

This paper demonstrates a gene drive strategy targeting KLHL10 in mice to increase homing efficiency by removing NHEJ-mutated sperm, but observes unexpected mutation absence in female offspring.

DOI 10.1177/25731599261452112

mouseexperimental assay

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