Increasing the effective gene drive homing rate by targeting the haploinsufficient spermatogenesis gene KLHL10
Ceili L. Peng, W. Sebastian Kamau, Julien Freeman, Zachary J Hill, Kevin M. Esvelt
This paper demonstrates a gene drive strategy targeting KLHL10 in mice to increase homing efficiency by removing NHEJ-mutated sperm, but observes unexpected mutation absence in female offspring.
The CRISPR Journal · Jun 1, 2026Peer-reviewedSynthetic Biology