A genetically encoded fluorescent sensor enables sensitive and specific detection of IDH mutant associated oncometabolite D-2-hydroxyglutarate
Kristian A. Choate, W. W. L. Konickson, Zoe Moreno, Olivia S. Brill, Brett C. Cromell, Bella M. Detienne, Matthew J. Jennings, Paul B. Mann, Robert J. Winn, David Olayinka. Kamson, Evan P.S. Pratt
This paper develops a genetically encoded fluorescent sensor, D2HGlo, for detecting D-2-HG, an oncometabolite associated with IDH mutations, and demonstrates its utility in diagnosing IDH mutant cancers.
BMC Cancer · Mar 14, 2025Peer-reviewedCancer Biology