Evan P.S. Pratt

This study shows that ERG1A overexpression in C2C12 myotubes reduces calsequestrin1 levels, leading to increased intracellular calcium concentration through modulation of calcium buffering.

This paper develops a genetically encoded fluorescent sensor, D2HGlo, for detecting D-2-HG, an oncometabolite associated with IDH mutations, and demonstrates its utility in diagnosing IDH mutant cancers.