The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin
Q. Cao, D. H. Anderson, W. Y. Liang, J. Chou, L. Saelices
This study investigates whether TTR's amyloidogenic ability and its anti-amyloid effect are linked, finding that TTR dissociation is necessary to inhibit Aβ toxicity and identifying a TTR segment that mimics its protective effect.
bioRxiv · Mar 11, 2020Biochemistry