J. Chou

Ixodes ricinus bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice.

This study shows that Ixodes ricinus bites in mice cause skin inflammation and intestinal changes similar to allergic reactions and red meat allergy predisposition.

Histologic variants in bladder cancer harbor aggressive molecular features including TM4SF1 expression and a CA125+ cell state

Single cell RNA sequencing of bladder cancer subtypes identified a CA125+ cell state linked to aggressive features and TM4SF1 as a therapeutic target.

CDK12 Loss Promotes Prostate Cancer Development While Exposing Vulnerabilities to Paralog-Based Synthetic Lethality

This study shows CDK12 loss drives prostate cancer development and identifies CDK13 as a therapeutic target through paralog-based synthetic lethality in CDK12-mutant tumors.

Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter.

The paper shows host-derived oxidized phospholipids initiate effector-triggered immunity, leading to lethality upon microbial encounter, and demonstrates that blocking oxPLs reduces inflammation and host death.

Treatment of prostate cancer with CD46 targeted 225Ac alpha particle radioimmunotherapy

This study develops and evaluates [225Ac]DOTA-YS5, a radioimmunotherapy for prostate cancer, showing high efficacy in xenograft models but nephrotoxicity at higher doses.

CUB domain containing protein 1 (CDPC1) is a target for radioligand therapy in castration resistant prostate cancer

This paper evaluates CDCP1 as a target for radioligand therapy in mCRPC, showing its expression in most biopsies and demonstrating antitumor effects with 177Lu-4A06.

Selective MAP1LC3C (LC3C) autophagy requires noncanonical initiation regulators and the paralog-specific C-terminal peptide

This study identifies noncanonical regulators and a C-terminal peptide essential for LC3C-mediated selective autophagy targeting PDMBs in cancer stem cells.

Autoantibody landscape of advanced prostate cancer

This study characterizes the autoantibody landscape in metastatic castration-resistant prostate cancer using serum epitope repertoire analysis and identifies novel tumor-specific epitopes.

The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin

This study investigates whether TTR's amyloidogenic ability and its anti-amyloid effect are linked, finding that TTR dissociation is necessary to inhibit Aβ toxicity and identifying a TTR segment that mimics its protective effect.

The physical form of microbial ligands bypasses the need for dendritic cell migration to stimulate adaptive immunity

This study shows that soluble fungal polysaccharides are immunosilent in peripheral tissues but become potent immunogens in draining lymph nodes without requiring dendritic cell migration.

A Drosophila metainflammation-blood tumor model links aspirin-triggered eicosanoid-like mediators to immune signaling

This paper uses a Drosophila model to show aspirin reduces metabolic inflammation and immune signaling by promoting 13-EFOX-L2 production, suggesting evolutionary conserved mechanisms for resolving inflammation.