L. Saelices

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.

O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

Disease-associated patterns of acetylation stabilize tau fibril formation

This study identifies acetylation patterns that drive tau fibril formation and shows their structural and functional role in tauopathies.

Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2

The paper identifies amyloid-forming segments in SARS-CoV-2 Nucleoprotein and designs peptide inhibitors based on their atomic structures to target Covid-19.

The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin

This study investigates whether TTR's amyloidogenic ability and its anti-amyloid effect are linked, finding that TTR dissociation is necessary to inhibit Aβ toxicity and identifying a TTR segment that mimics its protective effect.