DNA damage-induced PARP/ALC1 activation leads to Epithelial-to-Mesenchymal transition stimulating homologous recombination.
F. Rajabi, R. Smith, W.-Y. Liu-Bordes, M. Schertzer, S. Huet, J.-A. Londono-Vallejo
This study shows DNA damage activates PARP and ALC1 to induce EMT, which enhances DNA repair via RAD51, and PARP inhibitors block this process.
bioRxiv · Jan 16, 2024 · PreprintCancer Biology