Pluripotent stem cell derived models of neurological diseases reveal early transcriptional heterogeneity
Matan Sorek, Walaa Oweis, Malka Nissim‐Rafinia, Moria Maman, Shahar Simon, Cynthia C. Hession, Xian Adiconis, Sean Simmons, Neville E. Sanjana, Xi Shi, Congyi Lu, Jen Q. Pan, Xiaohong Xu, Mahmoud A. Pouladi, Lisa Ellerby, , Eran Meshorer
The paper uses scRNA-seq to show increased transcriptional heterogeneity in neurodegenerative disease models, suggesting early regulatory imbalances.
Genome biology · Mar 4, 2021Peer-reviewedMolecular Biology