Xiaohong Xu

This study investigates the role of HTT palmitoylation in Huntington disease by assessing its dysregulation in models and showing that modulating palmitoylation reduces mHTT toxicity.

The paper uses scRNA-seq to show increased transcriptional heterogeneity in neurodegenerative disease models, suggesting early regulatory imbalances.

The paper identifies novel modifier genes for Huntington disease by combining population-scale gene expression data with patient genomic data.