Eran Meshorer

BLISS reveals dynamic HP1α clusters in chromocenters of undifferentiated ESCs, showing they are hyperdynamic and have lower fluorescence lifetimes than FLIM-averaged values.

This study investigates the distinct roles of SETα and SETβ in early cell fate decisions using ESCs with inducible isoform-specific expression and identifies unique regulatory functions for each isoform.

RoAM reconstructs ancient methylomes and identifies differentially methylated regions, showing metabolic adaptations during the Neolithic transition.

The paper shows H3.3 deposition counteracts H3.1 enrichment at chromocenters in ESCs, affecting heterochromatin stability and cell survival.

This paper introduces FRETsael, a method to localize biomolecular interactions with nanometer accuracy using fluorescence lifetime imaging, achieving 20-30 nm resolution in simulations and experimental samples.

This study identifies SMARCAD1 and TOPBP1 as regulators of heterochromatin maintenance during the transition from 2C-like to pluripotent states in mouse embryos.

The paper presents a method to directly measure methylation in ancient DNA, showing it is cost-effective and applicable to a wide range of samples.

This study investigates TE activation in SARS-CoV-2 infection, finding it induces a weaker IFN response compared to other viruses, with TE expression and viral load explaining immune response diversity.

The paper uses scRNA-seq to show increased transcriptional heterogeneity in neurodegenerative disease models, suggesting early regulatory imbalances.

CloneSeq identifies rare cell subpopulations by combining clonal expansion with single-cell RNA-seq, revealing cancer stem-like cells and improved stemness in embryonic cells.

The paper identifies extensive methylation changes in genes related to facial and vocal anatomy in modern humans compared to ancient humans and chimpanzees.

The paper shows that DNA sequence repeat symmetry defines transcription factor and histone modification binding preferences across developmental layers in human embryonic stem cells.