Reconstructing the emergence of the human chorion via HIPPO-mediated trophoblast induction
Miaoci Zhang, Ryan L. Lim, Alice H. Reis, Walter Piszker, Wallis W Boyd, Athena D. Pagon, Aman Mahajan, Linlin Wu, Cheng Zhao, Sophie Petropoulos A, Carlotta Ronda, Mijo Simunovic
This study uses HIPPO pathway modulation to induce human trophectoderm and reconstruct chorion development in vitro, identifying key cell types and markers.
bioRxiv · Nov 18, 2025 · PreprintCell Biology