Cheng Zhao

This study uses HIPPO pathway modulation to induce human trophectoderm and reconstruct chorion development in vitro, identifying key cell types and markers.

The paper develops a comprehensive reference tool for human embryogenesis using integrated single-cell RNA-sequencing data to benchmark embryo models.

The paper identifies the guinea pig as a new model for human preimplantation development, showing similarities in lineage formation and gene expression patterns.

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

This study shows that PRC2 restricts naive pluripotent stem cells from differentiating into trophectoderm by maintaining bivalent promoters and H3K27me3 methylation.