Recurrent PD-L1 Structural Rearrangements in Natural Killer/T Cell Lymphoma Patients with Complete Response to PD-1 Blockade Therapy
Jing Quan Lim, Tiffany Pooi Ling Tang, Qingqing Cai, Daryl Chen Lung Tan, Maarja‐Liisa Nairismägi, Yurike Laurensia, Burton Kuan Hui Chia, Roujun Peng, Jabed Iqbal, Da Huang, Tammy Linlin Song, Wan Lu Pang, Daryl Ming Zhe Cheah, Cedric Chuan Young Ng, Vikneswari Rajasegaran, , Choon Kiat Ong
The paper identifies recurrent PD-L1 structural rearrangements and JAK3 mutations in NKTL patients achieving CR with PD-1 blockade therapy, suggesting genomic screening may improve patient selection.
bioRxiv · Aug 21, 2018 · PreprintGenomics