Burton Kuan Hui Chia

Bambu-Clump improves transcript discovery and quantification from single-cell and spatial long-read RNA-seq data by leveraging cell and cluster information.

The paper identifies recurrent PD-L1 structural rearrangements and JAK3 mutations in NKTL patients achieving CR with PD-1 blockade therapy, suggesting genomic screening may improve patient selection.

ConsensusDriver improves driver alteration prediction by combining multiple methods, increasing sensitivity by 20% across cancer types and individual patients.

The paper benchmarks computational metagenomics software using complex datasets, showing strengths and limitations in assembly, binning, and taxonomic profiling.